It covers all the well-being related topics: health, happiness, longevity, optimism, change, success, self-development, emotions, goals and many others. It’s all spiced with a reasonable amount of scientific scepticism that popular self-help books usually lack.
However, to my taste Tal speaks too slowly and the whole thing takes too much time. That’s why I would recommend actually downloading all episodes using one of the Youtube downloading services, such as Offliberty. And then listen to it using VLC or other player that allows you to increase playback speed 2x.
Here are the videos. It gets especially videos at 3-4th video.